Comparison of 99mTc-DTPA and urea for measuring cefepime concentrations in epithelial lining fluid
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چکیده
منابع مشابه
Fosfomycin concentrations in epithelial lining fluid in weaning piglets.
Respiratory diseases are one of the most important problems in modern intensive swine production (Gardner and Hird, 1990). These diseases are a common cause of morbidity and mortality in weaning pigs (Gardner and Hird, 1990; Galina et al., 1994; Dos̆en et al., 2007). The concentrations of antibiotics in epithelial lining fluid (ELF) reflect the antimicrobial activity for extracellular pathogens ...
متن کاملA comparison of three methods of measuring 99mTc-DTPA lung clearance and their repeatability.
The lung clearance of technetium-99m diethylenetriamine penta-acetic acid (99mTc-DTPA) is a measure of respiratory epithelial permeability. Many factors may contribute to the wide range of normal values, including the method of correction for background activity. The aim of this study was to compare three methods of analysis, including their repeatability. 99mTc-DTPA lung clearance imaging was ...
متن کاملEstimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution.
Bronchoalveolar lavage is a powerful technique for sampling the epithelial lining fluid (ELF) of the lower respiratory tract but also results in a significant dilution of that fluid. To quantify the apparent volume of ELF obtained by bronchoalveolar lavage, urea was used as an endogenous marker of ELF dilution. Since urea diffuses readily through the body, plasma and in situ ELF urea concentrat...
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The steady-state concentrations of meropenem and the β-lactamase inhibitor RPX7009 in plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations were obtained in 25 healthy, nonsmoking adult subjects. Subjects received a fixed combination of meropenem (2 g) and RPX7009 (2 g) administered every 8 h, as a 3-h intravenous infusion, for a total of three doses. A bronchoscopy...
متن کاملRelationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients.
Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (± standard deviation [SD]) ELF/plasma ratio was 12.5 ± 6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r(2) = 0.87), suggesting ...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2004
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.04.00106803